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Exposure into the glucuronide metabolite is 35 to forty times better than publicity into the mum or dad drug. In vitro details recommend that hydromorphone in clinically related concentrations has nominal probable to inhibit the activity of human hepatic CYP450 enzymes including CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.The proportion of clients with n